HMM Summary Page: TIGR01622

Functionsplicing factor, CC1-like family
Trusted Cutoff231.65
Domain Trusted Cutoff231.65
Noise Cutoff167.00
Domain Noise Cutoff167.00
Isology Typesubfamily
HMM Length500
Gene Ontology TermGO:0008380: RNA splicing biological_process
AuthorSelengut J
Entry DateAug 8 2002 12:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: PF00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR [4] and was included in the seed.
ReferencesRN [1] RM PMID: 9578630 RT Repeat-induced point mutations in Pad-1, a putative RNA splicing factor from Neurospora crassa, confer dominant lethal effects on ascus development. RA Kuldau GA, Raju NB, Glass NL. RL Fungal Genet Biol 1998 Mar;23(2):169-80 RN [2] RM PMID: 11704680 RT Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. RA Jung DJ, Na SY, Na DS, Lee JW. RL J Biol Chem 2002 Jan 11;277(2):1229-34 RN [3] RM PMID: 8227358 RT Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma. RA Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM. RL J Clin Invest 1993 Nov;92(5):2419-26 RN [4] RL TIGR, unpublished data