HMM Summary Page: TIGR01621

Functionpseudouridine synthase Rlu family protein, TIGR01621
Trusted Cutoff222.30
Domain Trusted Cutoff222.30
Noise Cutoff157.90
Domain Noise Cutoff157.90
Isology Typehypoth_equivalog
EC Number5.4.99.-
HMM Length217
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0001522: pseudouridine synthesis biological_process
GO:0004730: pseudouridylate synthase activity molecular_function
AuthorSunshine J, Selengut J
Entry DateAug 8 2002 11:37AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a clade of sequences within the pseudouridine synthase superfamily (PF00849). The superfamily includes E. coli proteins: RluA, RluB, RluC, RluD, and RsuA. The sequences modeled here are most closely related to RluA [1]. Neisseria, among those species hitting this model, does not appear to have an RluA homolog. It is presumed that these sequences function as pseudouridine synthases, although perhaps with different specificity.
ReferencesRN [1] RM PMID: 10383384 RT Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA. RA Raychaudhuri S, Niu L, Conrad J, Lane BG, Ofengand J. RL J Biol Chem. 1999 Jul 2;274(27):18880-6.