| Accession | TIGR01621 |
| Name | RluA-like |
| Function | pseudouridine synthase Rlu family protein, TIGR01621 |
| Trusted Cutoff | 222.30 |
| Domain Trusted Cutoff | 222.30 |
| Noise Cutoff | 157.90 |
| Domain Noise Cutoff | 157.90 |
| Isology Type | hypoth_equivalog |
| EC Number | 5.4.99.- |
| HMM Length | 217 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA and rRNA base modification |
| Gene Ontology Term | GO:0001522: pseudouridine synthesis biological_process |
| | GO:0004730: pseudouridylate synthase activity molecular_function |
| Author | Sunshine J, Selengut J |
| Entry Date | Aug 8 2002 11:37AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This model represents a clade of sequences within the pseudouridine synthase superfamily (PF00849). The superfamily includes E. coli proteins: RluA, RluB, RluC, RluD, and RsuA. The sequences modeled here are most closely related to RluA [1]. Neisseria, among those species hitting this model, does not appear to have an RluA homolog. It is presumed that these sequences function as pseudouridine synthases, although perhaps with different specificity. |
| References | RN [1]
RM PMID: 10383384
RT Functional effect of deletion and mutation of the Escherichia coli ribosomal RNA and tRNA pseudouridine synthase RluA.
RA Raychaudhuri S, Niu L, Conrad J, Lane BG, Ofengand J.
RL J Biol Chem. 1999 Jul 2;274(27):18880-6. |
