HMM Summary Page: TIGR01617

Functiontranscriptional regulator, Spx/MgsR family
Trusted Cutoff75.05
Domain Trusted Cutoff75.05
Noise Cutoff57.50
Domain Noise Cutoff57.50
Isology Typesubfamily
HMM Length117
Mainrole CategoryHypothetical proteins
Subrole CategoryConserved
AuthorHaft DH
Entry DateAug 2 2002 1:32PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a portion of the proteins within the larger set covered by Pfam model PF03960. That larger family includes a glutaredoxin-dependent arsenate reductase (TIGR00014). Characterized members of this family include Spx and MgsR from Bacillus subtili. Spx is a global regulator for response to thiol-specific oxidative stress. It interacts with RNA polymerase. MgsR (modulator of the general stress response, also called YqgZ) provides a second level of regulation for more than a third of the proteins in the B. subtilis general stress regulon controlled by Sigma-B.
ReferencesDR HAMAP; MF_01132; 34 of 34 RN [1] RM PMID:18687074 RT Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation. RA Reyes DY, Zuber P RL Mol Microbiol. 2008 Aug;69(3):765-79. RN [2] RM PMID:18643936 RT The Spx paralogue MgsR (YqgZ) controls a subregulon within the general stress response of Bacillus subtilis. RA Reder A, Hoper D, Weinberg C, Gerth U, Fraunholz M, Hecker M RL Mol Microbiol. 2008 Sep;69(5):1104-20. Epub 2008 Jul 14.