| Accession | TIGR01596 |
| Name | cas3_HD |
| Function | CRISPR-associated endonuclease Cas3-HD |
| Trusted Cutoff | 43.45 |
| Domain Trusted Cutoff | 43.45 |
| Noise Cutoff | 42.80 |
| Domain Noise Cutoff | 42.80 |
| Isology Type | equivalog_domain |
| EC Number | 3.1.-.- |
| HMM Length | 178 |
| Mainrole Category | Mobile and extrachromosomal element functions |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004521: endoribonuclease activity molecular_function |
| | GO:0043571: maintenance of CRISPR repeat elements biological_process |
| Author | Haft DH |
| Entry Date | Jul 22 2002 5:22PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | CRISPR/Cas systems are widespread, mobile systems for host defense against invasive elements such as phage. In these systems, Cas3 designates one of the core proteins shared widely by multiple types of CRISPR/Cas system. This HMM represents an HD-like endonuclease that occurs either separately or as the N-terminal region of Cas3, the helicase-containing CRISPR-associated protein. |
| References | DR URL http://www.tigr.org/tigr-scripts/CMR2/genome_property_def.spl?prop=2003
RN [1]
RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes
RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE
RL PLOS Comput. Biol. 1(6), e60-e69, 2005
RN [2]
RM 11952905
RT Identification of genes that are associated with DNA repeats in prokaryotes.
RA Jansen R, Embden JD, Gaastra W, Schouls LM.
RL Mol Microbiol 2002 Mar;43(6):1565-75
RN [3]
RM PMID:19174159
RT Characterization of the endonuclease SSO2001 from Sulfolobus solfataricus P2.
RA Han D, Krauss G
RL FEBS Lett. 2009 Feb 18;583(4):771-6. Epub 2009 Jan 25. |
| Genome Property | GenProp0021: CRISPR region (HMM) |
| | GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST) |
| | GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST) |
