HMM Summary Page: TIGR01596

FunctionCRISPR-associated endonuclease Cas3-HD
Trusted Cutoff43.45
Domain Trusted Cutoff43.45
Noise Cutoff42.80
Domain Noise Cutoff42.80
Isology Typeequivalog_domain
EC Number3.1.-.-
HMM Length178
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0004521: endoribonuclease activity molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateJul 22 2002 5:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentCRISPR/Cas systems are widespread, mobile systems for host defense against invasive elements such as phage. In these systems, Cas3 designates one of the core proteins shared widely by multiple types of CRISPR/Cas system. This HMM represents an HD-like endonuclease that occurs either separately or as the N-terminal region of Cas3, the helicase-containing CRISPR-associated protein.
ReferencesDR URL RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM 11952905 RT Identification of genes that are associated with DNA repeats in prokaryotes. RA Jansen R, Embden JD, Gaastra W, Schouls LM. RL Mol Microbiol 2002 Mar;43(6):1565-75 RN [3] RM PMID:19174159 RT Characterization of the endonuclease SSO2001 from Sulfolobus solfataricus P2. RA Han D, Krauss G RL FEBS Lett. 2009 Feb 18;583(4):771-6. Epub 2009 Jan 25.
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST)
GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST)