HMM Summary Page: TIGR01593

Functiontoxin secretion/phage lysis holin
Trusted Cutoff40.20
Domain Trusted Cutoff40.20
Noise Cutoff38.30
Domain Noise Cutoff38.30
Isology Typesubfamily
HMM Length128
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0008565: protein transporter activity molecular_function
GO:0019835: cytolysis biological_process
AuthorHaft DH, Fouts DE
Entry DateJul 19 2002 9:54AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes one of the many mutally dissimilar families of holins, phage proteins that act together with lytic enzymes in bacterial lysis. This family includes, besides phage holins, the protein TcdE/UtxA involved in toxin secretion in Clostridium difficile and related species.
ReferencesRM 11444771 RT Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile RA Tan KS, Wee BY, Song KP. RL J Med Microbiol 2001 Jul;50(7):613-9
Genome PropertyGenProp0208: phage: major features (HMM)