Accession | TIGR01593 |
Name | holin_tox_secr |
Function | toxin secretion/phage lysis holin |
Trusted Cutoff | 40.20 |
Domain Trusted Cutoff | 40.20 |
Noise Cutoff | 38.30 |
Domain Noise Cutoff | 38.30 |
Isology Type | subfamily |
HMM Length | 128 |
Mainrole Category | Protein fate |
Subrole Category | Protein and peptide secretion and trafficking |
Gene Ontology Term | GO:0008565: protein transporter activity molecular_function |
| GO:0019835: cytolysis biological_process |
Author | Haft DH, Fouts DE |
Entry Date | Jul 19 2002 9:54AM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM describes one of the many mutally dissimilar families of holins, phage proteins that act together with lytic enzymes in bacterial lysis. This family includes, besides phage holins, the protein TcdE/UtxA involved in toxin secretion in Clostridium difficile and related species. |
References | RM 11444771
RT Evidence for holin function of tcdE gene in the pathogenicity of Clostridium difficile
RA Tan KS, Wee BY, Song KP.
RL J Med Microbiol 2001 Jul;50(7):613-9 |
Genome Property | GenProp0208: phage: major features (HMM) |