HMM Summary Page: TIGR01588

Functioncitrate (pro-3S)-lyase, beta subunit
Gene SymbolcitE
Trusted Cutoff443.40
Domain Trusted Cutoff443.40
Noise Cutoff337.30
Domain Noise Cutoff337.30
Isology Typeequivalog
EC Number4.1.3.6
HMM Length288
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0006113: fermentation biological_process
GO:0008815: citrate (pro-3S)-lyase activity molecular_function
GO:0009346: citrate lyase complex cellular_component
AuthorDurkin S
Entry DateJul 16 2002 3:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis is a model of the beta subunit of the holoenzyme citrate lyase (EC composed of alpha (EC, beta (EC, and acyl carrier protein subunits in a stoichiometric relationship of 6:6:6. Citrate lyase is an enzyme which converts citrate to oxaloacetate. In bacteria, this reaction is involved in citrate fermentation. The beta subunit catalyzes the reaction (3S)-citryl-CoA = acetyl-CoA + oxaloacetate. The seed contains an experimentally characterized member from Leuconostoc mesenteroides [1]. The model covers a wide range of Gram positive bacteria. For Gram negative bacteria, it appears that only gamma proteobacteria hit this model. The model is quite robust with queries scoring either quite well or quite poorly against the model. There are currently no hits in-between the noise cutoff and trusted cutoff.
ReferencesRN [1] RM PMID: 9457870 RT Purification of Leuconostoc mesenteroides citrate lyase and cloning and characterization of the citCDEFG gene cluster. RA Bekal S, Van Beeumen J, Samyn B, Garmyn D, Henini S, Divies C, Prevost H RL J Bacteriol 1998 Feb;180(3):647-54
Genome PropertyGenProp0672: citrate lyase system (HMM)