| Accession | TIGR01587 |
| Name | cas3_core |
| Function | CRISPR-associated helicase Cas3 |
| Gene Symbol | cas3 |
| Trusted Cutoff | 102.45 |
| Domain Trusted Cutoff | 102.45 |
| Noise Cutoff | 93.10 |
| Domain Noise Cutoff | 93.10 |
| Isology Type | equivalog_domain |
| HMM Length | 358 |
| Mainrole Category | Mobile and extrachromosomal element functions |
| Subrole Category | Other |
| Gene Ontology Term | GO:0004386: helicase activity molecular_function |
| | GO:0043571: maintenance of CRISPR repeat elements biological_process |
| Author | Haft DH |
| Entry Date | Jul 16 2002 3:30PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by PF00270 (DEAD/DEAH box helicase) and PF00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (PF01966) that is not included within this model. |
| References | DR URL http://www.tigr.org/tigr-scripts/CMR2/genome_property_def.spl?prop=2003
DR PFAM; PF00270; DEAD/DEAH box helicase
DR PFAM; PF00271; Helicase conserved C-terminal domain
RN [1]
RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes
RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE
RL PLOS Comput. Biol. 1(6), e60-e69, 2005
RN [2]
RM 11952905
RT Identification of genes that are associated with DNA repeats in prokaryotes.
RA Jansen R, Embden JD, Gaastra W, Schouls LM.
RL Mol Microbiol 2002 Mar;43(6):1565-75
RN [3]
RM 11788711
RT A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis.
RA Makarova KS, Aravind L, Grishin NV, Rogozin IB, Koonin EV.
RL Nucleic Acids Res. 2002 Jan 15;30(2):482-96. |
| Genome Property | GenProp0021: CRISPR region (HMM) |
| | GenProp0313: CRISPR system, I-C/Dvulg subtype (HMM-CLUST) |
| | GenProp0315: CRISPR system, I-E/Ecoli subtype (HMM-CLUST) |
| | GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST) |
| | GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST) |
| | GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST) |
| | GenProp0768: CRISPR system, Pging subtype (HMM-CLUST) |
| | GenProp0922: CRISPR system, Myxan subtype (HMM-CLUST) |
