HMM Summary Page: TIGR01587

FunctionCRISPR-associated helicase Cas3
Gene Symbolcas3
Trusted Cutoff102.45
Domain Trusted Cutoff102.45
Noise Cutoff93.10
Domain Noise Cutoff93.10
Isology Typeequivalog_domain
HMM Length358
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0004386: helicase activity molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateJul 16 2002 3:30PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the highly conserved core region of an alignment of Cas3, a protein found in association with CRISPR repeat elements in a broad range of bacteria and archaea. Cas3 appears to be a helicase, with regions found by PF00270 (DEAD/DEAH box helicase) and PF00271 (Helicase conserved C-terminal domain). Some but not all members have an N-terminal HD domain region (PF01966) that is not included within this model.
ReferencesDR URL DR PFAM; PF00270; DEAD/DEAH box helicase DR PFAM; PF00271; Helicase conserved C-terminal domain RN [1] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [2] RM 11952905 RT Identification of genes that are associated with DNA repeats in prokaryotes. RA Jansen R, Embden JD, Gaastra W, Schouls LM. RL Mol Microbiol 2002 Mar;43(6):1565-75 RN [3] RM 11788711 RT A DNA repair system specific for thermophilic Archaea and bacteria predicted by genomic context analysis. RA Makarova KS, Aravind L, Grishin NV, Rogozin IB, Koonin EV. RL Nucleic Acids Res. 2002 Jan 15;30(2):482-96.
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0313: CRISPR system, I-C/Dvulg subtype (HMM-CLUST)
GenProp0315: CRISPR system, I-E/Ecoli subtype (HMM-CLUST)
GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST)
GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST)
GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST)
GenProp0768: CRISPR system, Pging subtype (HMM-CLUST)
GenProp0922: CRISPR system, Myxan subtype (HMM-CLUST)