HMM Summary Page: TIGR01584

Functioncitrate lyase, alpha subunit
Gene SymbolcitF
Trusted Cutoff501.45
Domain Trusted Cutoff501.45
Noise Cutoff284.70
Domain Noise Cutoff284.70
Isology Typeequivalog
EC Number2.8.3.10
HMM Length492
Mainrole CategoryEnergy metabolism
Subrole CategoryFermentation
Gene Ontology TermGO:0006113: fermentation biological_process
GO:0008814: citrate CoA-transferase activity molecular_function
GO:0008815: citrate (pro-3S)-lyase activity molecular_function
GO:0009346: citrate lyase complex cellular_component
AuthorDurkin S
Entry DateJul 12 2002 2:18PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis is a model of the alpha subunit of the holoenzyme citrate lyase (EC composed of alpha (EC, beta (EC, and acyl carrier protein subunits in a stoichiometric relationship of 6:6:6. Citrate lyase is an enzyme which converts citrate to oxaloacetate. In bacteria, this reaction is involved in citrate fermentation. The alpha subunit catalyzes the reaction Acetyl-CoA + citrate = acetate + (3S)-citryl-CoA. The seed contains an experimentally characterized member from Lactococcus lactis subsp. lactis [1]. The model covers both Gram positive and Gram negative bacteria. It is quite robust with queries scoring either quite well or quite poorly against the model. There are currently no hits in between the noise cutoff and trusted cutoff.
ReferencesRN [1] RM PMID: 1115558 RT Citrate lyase from Streptococcus diacetilactis. Association with its acetylating enzyme. RA Kummel A, Behrens G, Gottschalk G RL Arch Microbiol 1975;102(2):111-6
Genome PropertyGenProp0672: citrate lyase system (HMM)