HMM Summary Page: TIGR01583

Functionformate dehydrogenase, gamma subunit
Trusted Cutoff115.85
Domain Trusted Cutoff115.85
Noise Cutoff56.10
Domain Noise Cutoff56.10
Isology Typeequivalog
EC Number1.2.1.2
HMM Length204
Mainrole CategoryEnergy metabolism
Subrole CategoryAnaerobic
Gene Ontology TermGO:0008863: formate dehydrogenase (NAD+) activity molecular_function
GO:0009055: electron carrier activity molecular_function
GO:0009061: anaerobic respiration biological_process
GO:0009326: formate dehydrogenase complex cellular_component
AuthorSelengut J
Entry DateJul 10 2002 11:59AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the gamma chain of the gamma proteobacteria (and Aquifex aolicus) formate dehydrogenase. This subunit is integral to the cytoplasmic membrane, consisting of 4 transmembrane helices, and receives electrons from the beta subunit. The entire E. coli formate dehydrogenase N (nitrate-inducible form) has been crystallized [1]. The gamma subunit contains two cytochromes, heme b(P) and heme b(C) near the periplasmic and cytoplasmic sides of the membrane respectively. The electron acceptor quinone binds at the cytoplasmic heme histidine ligand. NiFe-hydrogenase and thiosulfate reductase contain homologous gamma subunits, and these can be found scoring in the noise of this model.
ReferencesRN [1] RM PMID: 11884747 RT Molecular basis of proton motive force generation: structure of formate dehydrogenase-N. RA Jormakka M, Tornroth S, Byrne B, Iwata S. RL Science. 2002 Mar 8;295(5561):1863-8.