HMM Summary Page: TIGR01582

Functionformate dehydrogenase, beta subunit
Gene SymbolfdxH
Trusted Cutoff334.70
Domain Trusted Cutoff334.70
Noise Cutoff152.40
Domain Noise Cutoff152.40
Isology Typeequivalog
EC Number1.2.1.2
HMM Length283
Mainrole CategoryEnergy metabolism
Subrole CategoryAnaerobic
Gene Ontology TermGO:0008863: formate dehydrogenase (NAD+) activity molecular_function
GO:0045333: cellular respiration biological_process
GO:0055114: oxidation-reduction process biological_process
AuthorSelengut J
Entry DateJul 10 2002 11:31AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents the beta subunit of the gamma-proteobacterial formate dehydrogenase. This subunit contains four 4Fe-4S clusters and is involved in transmitting electrons from the alpha subunit (TIGR01553) at the periplasmic space to the gamma subunit which spans the cytoplasmic membrane [1]. In addition to the gamma proteobacteria, a sequence from Aquifex aolicus falls within the scope of this model. This appears to be the case for the alpha, gamma and epsilon (accessory protein TIGR01562) chains as well.
ReferencesRN [1] RM PMID: 11884747 RT Molecular basis of proton motive force generation: structure of formate dehydrogenase-N. RA Jormakka M, Tornroth S, Byrne B, Iwata S. RL Science. 2002 Mar 8;295(5561):1863-8.