HMM Summary Page: TIGR01581

FunctionNifC-like ABC-type porter
Trusted Cutoff210.30
Domain Trusted Cutoff210.30
Noise Cutoff202.60
Domain Noise Cutoff202.60
Isology Typehypoth_equivalog
HMM Length225
Gene Ontology TermGO:0006810: transport biological_process
GO:0042626: ATPase activity, coupled to transmembrane movement of substances molecular_function
GO:0043190: ATP-binding cassette (ABC) transporter complex cellular_component
AuthorSelengut J
Entry DateJul 10 2002 9:34AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes a clade of ABC porter genes with relatively weak homology compared to its neighbor clades, the molybdate (TIGR02141) and sulfate (TIGR00969) porters. Neighbor-Joining, PAM-distance phylogenetic trees support the separation of the clades in this way. Included in this group is a gene designated NifC in Clostridium pasturianum [1]. It would be reasonable to presume that NifC acts as a molybdate porter since the most common form of nitrogenase is a molybdoenzyme. Several other sequences falling within the scope of this model are annotated as molybdate porters and one, from Halobacterium, is annotated as a sulfate porter. There is presently no experimental evidence to support annotations with this degree of specificity.
ReferencesRN [1] RM PMID: 2194453 RT A nitrogen-fixation gene (nifC) in Clostridium pasteurianum with sequence similarity to chlJ of Escherichia coli. RA Wang SZ, Chen JS, Johnson JL. RL Biochem Biophys Res Commun. 1990 Jun 29;169(3):1122-8.