HMM Summary Page: TIGR01573

FunctionCRISPR-associated endonuclease Cas2
Gene Symbolcas2
Trusted Cutoff24.50
Domain Trusted Cutoff24.50
Noise Cutoff22.00
Domain Noise Cutoff22.00
Isology Typeequivalog
HMM Length96
Mainrole CategoryMobile and extrachromosomal element functions
Subrole CategoryOther
Gene Ontology TermGO:0004521: endoribonuclease activity molecular_function
GO:0043571: maintenance of CRISPR repeat elements biological_process
AuthorHaft DH
Entry DateJul 2 2002 1:35PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes most members of the family of Cas2, one of the first four protein families found to mark prokaryotic genomes that contain multiple CRISPR elements. CRISPR systems protect against invasive nucleic acid sequences, including phage. Cas2 proteins have been characterized as either endoribonuclease (for ssRNA) or endodeoxyribonuclease (for dsDNA), depending on the system to which the Cas2 belongs. CRISPR is an acronym for Clustered Regularly Interspaced Short Palindromic Repeats. The cas genes usually are found near the repeats. A distinct branch of the Cas2 family shows a very low level of sequence identity and is modeled by TIGR01873 instead of by this HMM (TIGR01573).
ReferencesRN [1] RM PMID:22942283 RT Double-stranded endonuclease activity in Bacillus halodurans clustered regularly interspaced short palindromic repeats (CRISPR)-associated Cas2 protein. RA Nam KH, Ding F, Haitjema C, Huang Q, DeLisa MP, Ke A RL J Biol Chem. 2012 Oct 19;287(43):35943-52. RN [2] RM PMID:18482976 RT A novel family of sequence-specific endoribonucleases associated with the clustered regularly interspaced short palindromic repeats. RA Beloglazova N, Brown G, Zimmerman MD, Proudfoot M, Makarova KS, Kudritska M, Kochinyan S, Wang S, Chruszcz M, Minor W, Koonin EV, Edwards AM, Savchenko A, Yakunin AF RL J Biol Chem. 2008 Jul 18;283(29):20361-71. Epub 2008 May 15. RN [3] RT A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/cas subtypes exist in prokaryotic genomes RA Haft DH, Selengut JD, Mongodin EF, Nelsen KE RL PLOS Comput. Biol. 1(6), e60-e69, 2005 RN [4] RM 11952905 RT Identification of genes that are associated with DNA repeats in prokaryotes. RA Jansen R, Embden JD, Gaastra W, Schouls LM. RL Mol Microbiol 2002 Mar;43(6):1565-75
Genome PropertyGenProp0021: CRISPR region (HMM)
GenProp0313: CRISPR system, I-C/Dvulg subtype (HMM-CLUST)
GenProp0314: CRISPR system, II/Nmeni subtype (HMM-CLUST)
GenProp0317: CRISPR system, I-B subtype, Tneap branch (HMM-CLUST)
GenProp0319: CRISPR system, I-A/Apern subtype (HMM-CLUST)
GenProp0320: CRISPR system, I-B subtype, Hmari branch (HMM-CLUST)
GenProp0318: CRISPR system, III-A/Mtube subtype (HMM-CLUST)
GenProp0469: CRISPR system, Dpsyc subtype (HMM-CLUST)
GenProp0768: CRISPR system, Pging subtype (HMM-CLUST)
GenProp0922: CRISPR system, Myxan subtype (HMM-CLUST)
GenProp1061: CRISPR system, PreFran subtype (HMM-CLUST)