HMM Summary Page: TIGR01561

Functionputative glycogen debranching enzyme, archaeal type
Trusted Cutoff364.15
Domain Trusted Cutoff364.15
Noise Cutoff52.55
Domain Noise Cutoff52.55
Isology Typehypoth_equivalog
HMM Length569
Mainrole CategoryEnergy metabolism
Subrole CategoryBiosynthesis and degradation of polysaccharides
Gene Ontology TermGO:0004133: glycogen debranching enzyme activity molecular_function
GO:0005980: glycogen catabolic process biological_process
AuthorDurkin S
Entry DateJun 21 2002 5:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe seed for this model is composed of two uncharacterized archaeal proteins from Methanosarcina acetivorans and Sulfolobus solfataricus. Trusted cutoff is set so that essentially only archaeal members hit the model. The notable exceptions to archaeal membership are the Gram positive Clostridium perfringens which scores much better than some other archaea and the Cyanobacterium Nostoc sp. which scores just above the trusted cutoff. Noise cutoff is set to exclude the characterized eukaryotic glycogen debranching enzyme in S. cerevisiae. These cutoffs leave the prokaryotes Porphyromonas gingivalis and Deinococcus radiodurans below trusted but above noise. Multiple alignments including these last two species exhibit sequence divergence which may suggest a subtly different function for these prokaryotic proteins.
Genome PropertyGenProp0168: glycogen system (HMM)