HMM Summary Page: TIGR01552

Functionprevent-host-death family protein
Trusted Cutoff20.80
Domain Trusted Cutoff20.80
Noise Cutoff20.40
Domain Noise Cutoff20.40
Isology Typesubfamily
HMM Length53
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
Gene Ontology TermGO:0008219: cell death biological_process
AuthorHaft DH
Entry DateJun 14 2002 9:08AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM recognizes a region of about 55 amino acids toward the N-terminal end of bacterial proteins of about 85 amino acids in length. The best-characterized member is prevent-host-death (phd) of bacteriophage P1, the antidote partner of death-on-curing (doc) (TIGR01550) in an addiction module. Addiction modules prevent plasmid curing by killing the host cell as the longer-lived killing protein persists while the gene for the shorter-lived antidote is lost. Note, however, that relatively few members of this family appear to be plasmid or phage-encoded. Also, there is little overlap, except for phage P1 itself, of species with this family and with the doc family.
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)
GenProp0324: addiction module, RelE-RelB class (HMM)