| Accession | TIGR01552 |
| Name | phd_fam |
| Function | prevent-host-death family protein |
| Trusted Cutoff | 20.80 |
| Domain Trusted Cutoff | 20.80 |
| Noise Cutoff | 20.40 |
| Domain Noise Cutoff | 20.40 |
| Isology Type | subfamily |
| HMM Length | 53 |
| Mainrole Category | Cellular processes |
| Subrole Category | Toxin production and resistance |
| Gene Ontology Term | GO:0008219: cell death biological_process |
| Author | Haft DH |
| Entry Date | Jun 14 2002 9:08AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM recognizes a region of about 55 amino acids toward the N-terminal end of bacterial proteins of about 85 amino acids in length. The best-characterized member is prevent-host-death (phd) of bacteriophage P1, the antidote partner of death-on-curing (doc) (TIGR01550) in an addiction module. Addiction modules prevent plasmid curing by killing the host cell as the longer-lived killing protein persists while the gene for the shorter-lived antidote is lost. Note, however, that relatively few members of this family appear to be plasmid or phage-encoded. Also, there is little overlap, except for phage P1 itself, of species with this family and with the doc family. |
| Genome Property | GenProp0321: toxin-antitoxin system, type II (HMM) |
| | GenProp0324: addiction module, RelE-RelB class (HMM) |
