HMM Summary Page: TIGR01550

Functiondeath-on-curing family protein
Trusted Cutoff38.65
Domain Trusted Cutoff38.65
Noise Cutoff38.30
Domain Noise Cutoff38.30
Isology Typesubfamily
HMM Length122
Mainrole CategoryUnknown function
Subrole CategoryGeneral
AuthorHaft DH
Entry DateJun 13 2002 12:08PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe characterized member of this family is the death-on-curing (DOC) protein of phage P1. It is part of a two protein operon with prevents-host-death (phd) that forms an addiction module. DOC lacks homology to analogous addiction module post-segregational killing proteins involved in plasmid maintenance. These modules work as a combination of a long lived poison (e.g. this protein) and a more abundant but shorter lived antidote. Members of this family have a well-conserved central motif HxFx[ND][AG]NKR. A similar region, with K replaced by G, is found in the huntingtin interacting protein (HYPE) family.
ReferencesRN [1] RM 8411153 RT Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. RA Lehnherr H, Maguin E, Jafri S, Yarmolinsky MB. RL J Mol Biol 1993 Oct 5;233(3):414-28 DR EXPERIMENTAL; SP:Q06259; Bacteriophage P1
Genome PropertyGenProp0321: toxin-antitoxin system, type II (HMM)