| Accession | TIGR01550 |
| Name | DOC_P1 |
| Function | death-on-curing family protein |
| Trusted Cutoff | 38.65 |
| Domain Trusted Cutoff | 38.65 |
| Noise Cutoff | 38.30 |
| Domain Noise Cutoff | 38.30 |
| Isology Type | subfamily |
| HMM Length | 122 |
| Mainrole Category | Unknown function |
| Subrole Category | General |
| Author | Haft DH |
| Entry Date | Jun 13 2002 12:08PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | The characterized member of this family is the death-on-curing (DOC) protein of phage P1. It is part of a two protein operon with prevents-host-death (phd) that forms an addiction module. DOC lacks homology to analogous addiction module post-segregational killing proteins involved in plasmid maintenance. These modules work as a combination of a long lived poison (e.g. this protein) and a more abundant but shorter lived antidote.
Members of this family have a well-conserved central motif HxFx[ND][AG]NKR.
A similar region, with K replaced by G, is found in the huntingtin interacting protein (HYPE) family. |
| References | RN [1]
RM 8411153
RT Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained.
RA Lehnherr H, Maguin E, Jafri S, Yarmolinsky MB.
RL J Mol Biol 1993 Oct 5;233(3):414-28
DR EXPERIMENTAL; SP:Q06259; Bacteriophage P1 |
| Genome Property | GenProp0321: toxin-antitoxin system, type II (HMM) |
