HMM Summary Page: TIGR01546

Functionglyceraldehyde-3-phosphate dehydrogenase, type II
Trusted Cutoff232.90
Domain Trusted Cutoff232.90
Noise Cutoff56.25
Domain Noise Cutoff56.25
Isology Typeequivalog
EC Number1.2.1.59
HMM Length333
AuthorSelengut J
Entry DateJun 12 2002 11:36AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the type II glyceraldehyde-3-phosphate dehydrogenases which are limited to archaea. These enzymes catalyze the interconversion of 1,3-diphosphoglycerate and glyceraldehyde-3-phosphate, a central step in glycolysis and gluconeogenesis. In archaea, either NAD or NADP may be utilized as the cofactor. The class I GAPDH's from bacteria and eukaryotes are covered by TIGR01534. All of the members of the seed are characterized. See, for instance [1]. This model is very solid, there are no species falling between trusted and noise at this time. The closest relatives scoring in the noise are the class I GAPDH's.
ReferencesRN [1] RM PMID: 2165475 RT Glyceraldehyde-3-phosphate dehydrogenase from the hyperthermophilic archaebacterium Pyrococcus woesei: characterization of the enzyme, cloning and sequencing of the gene, and expression in Escherichia coli. RA Zwickl P, Fabry S, Bogedain C, Haas A, Hensel R. RL J Bacteriol 1990 Aug;172(8):4329-38. DR HAMAP; MF_00559; 43 of 43
Genome PropertyGenProp0691: glycolysis (HMM)