HMM Summary Page: TIGR01545

FunctionHAD hydrolase, family IF
Gene Symbolyfhb
Trusted Cutoff259.25
Domain Trusted Cutoff259.25
Noise Cutoff204.50
Domain Noise Cutoff204.50
Isology Typehypoth_equivalog
HMM Length210
Gene Ontology TermGO:0016787: hydrolase activity molecular_function
AuthorSelengut J
Entry DateJun 12 2002 10:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a clade of sequences limited to the gamma proteobacteria. This group is a member of the haloacid dehalogenase (HAD) superfamily of aspartate-dependent hydrolases and all of the conserved catalytic motifs are present [1]. Although structurally similar to subfamily IA in that the variable domain is predicted to consist of five consecutive alpha helices (by PSI-PRED), it is sufficiently divergent to warrant being regarded as a separate sub-family (IF). The gene name comes from the E. coli gene. There is currently no information regarding the function of this gene.
ReferencesRN [1] RM PMID: 7966317 RT Computer analysis of bacterial haloacid dehalogenases defines a large superfamily of hydrolases with diverse specificity. Application of an iterative approac h to database search. RA Koonin EV, Tatusov RL. RL J Mol Biol 1994 Nov 18;244(1):125-32