HMM Summary Page: TIGR01536

Functionasparagine synthase (glutamine-hydrolyzing)
Gene SymbolasnB
Trusted Cutoff267.10
Domain Trusted Cutoff267.10
Noise Cutoff159.05
Domain Noise Cutoff159.05
Isology Typeequivalog
EC Number6.3.5.4
HMM Length517
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryAspartate family
Gene Ontology TermGO:0004066: asparagine synthase (glutamine-hydrolyzing) activity molecular_function
GO:0006529: asparagine biosynthetic process biological_process
AuthorHaft DH
Entry DateJun 6 2002 3:44PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the glutamine-hydrolysing asparagine synthase. A poorly conserved C-terminal extension was removed from the model. Bacterial members of the family tend to have a long, poorly conserved insert lacking from archaeal and eukaryotic sequences. Multiple isozymes have been demonstrated, such as in Bacillus subtilis. Long-branch members of the phylogenetic tree (which typically were also second or third candidate members from their genomes) were removed from the seed alignment and score below trusted cutoff.
ReferencesDR PFAM; PF00733; Asn_synthase DR PFAM; PF00310; GATase_2 RN [1] RM 10498721 RT Three asparagine synthetase genes of Bacillus subtilis. RA Yoshida K, Fujita Y, Ehrlich SD. RL J Bacteriol 1999 Oct;181(19):6081-91
Genome PropertyGenProp0652: exopolysaccharide biosynthesis, exosortase A-associated (HMM-CLUST)
GenProp0259: tRNA-Asn direct aminoacylation (HMM)