HMM Summary Page: TIGR01530

FunctionNAD nucleotidase
Gene SymbolnadN
Trusted Cutoff436.00
Domain Trusted Cutoff436.00
Noise Cutoff253.50
Domain Noise Cutoff253.50
Isology Typeequivalog
EC Number3.1.3.5
HMM Length550
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0000210: NAD+ diphosphatase activity molecular_function
GO:0008253: 5'-nucleotidase activity molecular_function
GO:0019677: NAD catabolic process biological_process
GO:0030288: outer membrane-bounded periplasmic space cellular_component
GO:0051181: cofactor transport biological_process
AuthorHaft DH
Entry DateJun 5 2002 11:36AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes NadN of Haemophilus influenzae and a small number of close homologs in pathogenic, Gram-negative bacteria. NadN is a periplasmic enzyme that cleaves NAD (nicotinamide adenine dinucleotide) to NMN (nicotinamide mononucleotide) and AMP. The NMN must be converted by a 5'-nucleotidase to nicotinamide riboside for import. NadN belongs a large family of 5'-nucleotidases and has NMN 5'-nucleotidase activity for NMN, AMP, etc.
ReferencesRN [1] RM 11395461 RT NadN and e (P4) are essential for utilization of NAD and nicotinamide mononucleotide but not nicotinamide riboside in Haemophilus influenzae. RA Kemmer G, Reilly TJ, Schmidt-Brauns J, Zlotnik GW, Green BA, Fiske MJ, Herbert M, Kraiss A, Schlor S, Smith A, Reidl J. RL J Bacteriol. 2001 Jul;183(13):3974-81.