HMM Summary Page: TIGR01529

Functionarginine repressor
Gene SymbolargR
Trusted Cutoff130.45
Domain Trusted Cutoff130.45
Noise Cutoff67.20
Domain Noise Cutoff67.20
Isology Typeequivalog
HMM Length146
Mainrole CategoryAmino acid biosynthesis
Subrole CategoryGlutamate family
Gene Ontology TermGO:0006525: arginine metabolic process biological_process
GO:0016564: transcription repressor activity molecular_function
AuthorHaft DH
Entry DateJun 4 2002 3:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM includes most members of the arginine-responsive transcriptional regulator family ArgR. This hexameric protein binds DNA at its amino end to repress arginine biosyntheis or activate arginine catabolism. Some species have several ArgR paralogs. In a neighbor-joining tree, some of these paralogous sequences show long branches and differ significantly in an otherwise well-conserved C-terminal region motif GT[VIL][AC]GDDT. These paralogs are excluded from the seed and score in the gray zone of this model, between trusted and noise cutoffs.
References DR HAMAP; MF_00173; 169 of 192