HMM Summary Page: TIGR01528

Functionnicotinamide mononucleotide transporter PnuC
Gene SymbolpnuC
Trusted Cutoff42.45
Domain Trusted Cutoff42.45
Noise Cutoff37.95
Domain Noise Cutoff37.95
Isology Typesubfamily
HMM Length187
Mainrole CategoryTransport and binding proteins
Subrole CategoryOther
Gene Ontology TermGO:0015663: nicotinamide mononucleotide transmembrane transporter activity molecular_function
GO:0015890: nicotinamide mononucleotide transport biological_process
GO:0016021: integral to membrane cellular_component
AuthorHaft DH
Entry DateJun 3 2002 4:16PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe PnuC protein of E. coli is membrane protein responsible for nicotinamide mononucleotide transport, subject to regulation by interaction with the NadR (also called NadI) protein (see TIGR01526). This HMM defines a region corresponding to most of the length of PnuC, found primarily in pathogens. The extreme N- and C-terminal regions are poorly conserved and not included in the alignment and model.
ReferencesRM 1991724 RT Activity of the nicotinamide mononucleotide transport system is regulated in Salmonella typhimurium. RA Zhu N, Olivera BM, Roth JR. RL J Bacteriol 1991 Feb;173(3):1311-20