HMM Summary Page: TIGR01527

Functionnicotinamide-nucleotide adenylyltransferase
Trusted Cutoff181.20
Domain Trusted Cutoff181.20
Noise Cutoff73.45
Domain Noise Cutoff73.45
Isology Typeequivalog
EC Number2.7.7.1
HMM Length167
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPyridine nucleotides
Gene Ontology TermGO:0000309: nicotinamide-nucleotide adenylyltransferase activity molecular_function
GO:0009435: NAD biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 31 2002 10:28AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes a family of archaeal proteins with the activity of the NAD salvage biosynthesis enzyme nicotinamide-nucleotide adenylyltransferase (EC In some cases, the enzyme was tested and found also to have the activity of nicotinate-nucleotide adenylyltransferase (EC, an enzyme of NAD de novo biosynthesis, although with a higher Km. In some archaeal species, a lower-scoring paralog, uncharacterized with respect to activity, is also present. These score between trusted and noise cutoffs.
ReferencesRM 9401030 RT Characterization of nicotinamide mononucleotide adenylyltransferase from thermophilic archaea. RA Raffaelli N, Pisani FM, Lorenzi T, Emanuelli M, Amici A, Ruggieri S, Magni G. RL J Bacteriol. 1997 Dec;179(24):7718-23. DR HAMAP; MF_00243; 33 of 36
Genome PropertyGenProp0057: NAD(P) biosynthesis from L-aspartate and DHAP (HMM)