HMM Summary Page: TIGR01524

Functionmagnesium-translocating P-type ATPase
Gene SymbolmgtA
Trusted Cutoff610.75
Domain Trusted Cutoff610.75
Noise Cutoff563.35
Domain Noise Cutoff563.35
Isology Typeequivalog
EC Number3.6.3.2
HMM Length867
Mainrole CategoryTransport and binding proteins
Subrole CategoryCations and iron carrying compounds
Gene Ontology TermGO:0015444: magnesium-importing ATPase activity molecular_function
GO:0015693: magnesium ion transport biological_process
AuthorSelengut J
Entry DateMay 24 2002 12:22PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes the magnesium translocating P-type ATPase found in a limited number of bacterial species and best described in Salmonella typhimurium, which contains two isoforms [1]. These transporters are active in low external Mg2+ concentrations and pump the ion into the cytoplasm. The magnesium ATPases have been classified as type IIIB by a phylogenetic analysis [2].
ReferencesRN [1] RM PMID: 1328179 RT MgtA and MgtB: prokaryotic P-type ATPases that mediate Mg2+ influx. RA Maguire ME. RL J Bioenerg Biomembr 1992 Jun;24(3):319-28 RN [2] RM PMID:9419228 RT Evolution of Substrate Specificities in the P-type ATPase Superfamily. RA Axelsen KB, Palmgren, MG. RL J Mol Evol. 1998 Jan; 46(1): 84-101.