HMM Summary Page: TIGR01523

Functionpotassium/sodium efflux P-type ATPase, fungal-type
Trusted Cutoff645.05
Domain Trusted Cutoff645.05
Noise Cutoff306.45
Domain Noise Cutoff306.45
Isology Typeequivalog
EC Number3.6.3.-
HMM Length997
AuthorSelengut J
Entry DateMay 23 2002 2:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentInitially described as a calcium efflux ATPase [1], more recent work has shown that the S. pombe CTA3 gene is in fact a potassium ion efflux pump [2]. This HMM describes the clade of fungal P-type ATPases responsible for potassium and sodium efflux. The degree to which these pumps show preference for sodium or potassium varies. This group of ATPases has been classified by phylogentic analysis as type IID [3]. The Leishmania sequence (GP|3192903), which falls between trusted and noise in this model, may very well turn out to be an active potassium pump.
ReferencesRN [1] RM PMID: 1323458 RT An intracellular ATP-dependent calcium pump within the yeast Schizosaccharomyces pombe, encoded by the gene cta3. RA Halachmi D, Ghislain M, Eilam Y. RL Eur J Biochem. 1992 Aug 1;207(3):1003-8. RN [3] RM PMID:9419228 RT Evolution of Substrate Specificities in the P-type ATPase Superfamily. RA Axelsen KB, Palmgren, MG. RL J Mol Evol. 1998 Jan; 46(1): 84-101. RN [2] RM PMID: 11932440 RT Potassium- or sodium-efflux ATPase, a key enzyme in the evolution of fungi. RA Benito B, Garciadeblas B, Rodriguez-Navarro A. RL Microbiology. 2002 Apr;148(Pt 4):933-41.