HMM Summary Page: TIGR01520

Functionfructose-bisphosphate aldolase, class II
Gene SymbolfbaA
Trusted Cutoff347.70
Domain Trusted Cutoff347.70
Noise Cutoff206.25
Domain Noise Cutoff206.25
Isology Typeequivalog
EC Number4.1.2.13
HMM Length357
Mainrole CategoryEnergy metabolism
Subrole CategoryGlycolysis/gluconeogenesis
Gene Ontology TermGO:0004332: fructose-bisphosphate aldolase activity molecular_function
GO:0006096: glycolysis biological_process
AuthorHaft DH
Entry DateMay 22 2002 3:25PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are class II examples of the glycolytic enzyme fructose-bisphosphate aldolase (FBA). This HMM represents one of two deeply split, architecturally distinct clades of the family that includes class II fructose-bisphosphate aldolases, tagatose-bisphosphate aldolases, and related uncharacterized proteins. This family is well-conserved and includes characterized FBA from Saccharomyces cerevisiae, Escherichia coli, and Corynebacterium glutamicum. Proteins outside the scope of this model may also be designated as class II fructose-bisphosphate aldolases, but are well separated in an alignment-based phylogenetic tree.
ReferencesDR EXPERIMENTAL; SP|P14540; Saccharomyces cerevisiae DR EXPERIMENTAL; SP|P19537; Corynebacterium glutamicum DR EXPERIMENTAL; SP|P11604; Escherichia coli
Genome PropertyGenProp0120: pentose phosphate cycle (HMM)
GenProp0691: glycolysis (HMM)