HMM Summary Page: TIGR01517

Functioncalcium-translocating P-type ATPase, PMCA-type
Trusted Cutoff507.05
Domain Trusted Cutoff507.05
Noise Cutoff275.90
Domain Noise Cutoff275.90
Isology Typeequivalog
EC Number3.6.3.8
HMM Length882
Gene Ontology TermGO:0005388: calcium-transporting ATPase activity molecular_function
GO:0006816: calcium ion transport biological_process
AuthorSelengut J
Entry DateMay 21 2002 10:10AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the P-type ATPase responsible for translocating calcium ions across the plasma membrane of eukaryotes [1], out of the cell. In some organisms, this type of pump may also be found in vacuolar membranes [2]. In humans and mice, at least, there are multiple isoforms of the PMCA pump with overlapping but not redundant functions. Accordingly, there are no human diseases linked to PMCA defects, although alterations of PMCA function do elicit physiological effects [3]. The calcium P-type ATPases have been characterized as Type IIB based on a phylogenetic analysis which distinguishes this group from the Type IIA SERCA calcium pump [4]. A separate analysis divides Type IIA into sub-types (SERCA and PMR1) [5] which are modelled by two corresponding HMMs (TIGR01116 and TIGR01522). This HMM is well separated from those.
ReferencesRN [1] RM PMID: 10434059 RT Developmental expression of the four plasma membrane calcium ATPase (Pmca) genes in the mouse RA Zacharias DA, Kappen C. RL Biochim. Biophys. Acta. 1999 Aug 5;1428(2-3):397-405. RN [2] RM PMID: 10802325 RT Vacuolar localization of an Entamoeba histolytica homologue of the plasma membrane ATPase (PMCA). RA Ghosh SK, Rosenthal B, Rogers R, Samuelson J. RL Mol Biochem Parasitol 2000 Apr 30;108(1):125-30 RN [3] RM PMID: 11779702 RT The role of plasma membrane Ca2+ pumps (PMCAs) in pathologies of mammalian cells. RA Lehotsky J, Kaplan P, Murin R, Raeymaekers L. RL Front Biosci 2002 Jan 1;7:d53-84 RN [4] RM PMID:9419228 RT Evolution of Substrate Specificities in the P-type ATPase Superfamily. RA Axelsen KB, Palmgren, MG. RL J Mol Evol. 1998 Jan; 46(1): 84-101. RN [5] RM PMID: 10433975 RT Two additional type IIA Ca(2+)-ATPases are expressed in Arabidopsis thaliana: evidence that type IIA sub-groups exist. RA Pittman JK, Mills RF, O'Connor CD, Williams LE. RL Gene 1999 Aug 5;236(1):137-47