HMM Summary Page: TIGR01510

Functionpantetheine-phosphate adenylyltransferase
Gene SymbolcoaD
Trusted Cutoff103.30
Domain Trusted Cutoff103.30
Noise Cutoff72.75
Domain Noise Cutoff72.75
Isology Typeequivalog
EC Number2.7.7.3
HMM Length155
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryPantothenate and coenzyme A
Gene Ontology TermGO:0004595: pantetheine-phosphate adenylyltransferase activity molecular_function
GO:0015937: coenzyme A biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 16 2002 4:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes pantetheine-phosphate adenylyltransferase, the penultimate enzyme of coenzyme A (CoA) biosynthesis in bacteria. It does not show any strong homology to eukaryotic enzymes of coenzyme A biosynthesis. This protein was previously designated KdtB and postulated (because of cytidyltransferase homology and proximity to kdtA) to be an enzyme of LPS biosynthesis, a cytidyltransferase for 3-deoxy-D-manno-2-octulosonic acid. However, no activity toward that compound was found with either CTP or ATP. The phylogenetic distribution of this enzyme is more consistent with coenzyme A biosynthesis than with LPS biosynthesis.
ReferencesRM 10480925 RT Purification and characterization of phosphopantetheine adenylyltransferase from Escherichia coli. RA Geerlof A, Lewendon A, Shaw WV. RL J Biol Chem 1999 Sep 17;274(38):27105-11 DR HAMAP; MF_00151; 431 of 437
Genome PropertyGenProp0171: coenzyme A biosynthesis from pantothenate (HMM)