HMM Summary Page: TIGR01508

Functiondiaminohydroxyphosphoribosylaminopyrimidine reductase
Trusted Cutoff186.45
Domain Trusted Cutoff186.45
Noise Cutoff165.85
Domain Noise Cutoff165.85
Isology Typeequivalog
EC Number1.1.1.-
HMM Length210
AuthorHaft DH, Selengut J
Entry DateMay 15 2002 3:10PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents a specific reductase of riboflavin biosynthesis in the Archaea, diaminohydroxyphosphoribosylaminopyrimidine reductase. It should not be confused with bacterial 5-amino-6-(5-phosphoribosylamino)uracil reductase. The intermediate 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine in riboflavin biosynthesis is reduced first, and then deaminated, in both Archaea and Fungi, opposite the order in Bacteria. The subsequent deaminase is not presently known and is not closely homologous to the deaminase domain ( fused to the reductase domain ( similar to this protein but found in most bacteria.
ReferencesRM 11889103 RT The pyrimidine nucleotide reductase step in riboflavin and F(420) biosynthesis in archaea proceeds by the eukaryotic route to riboflavin. RA Graupner M, Xu H, White RH. RL J Bacteriol 2002 Apr;184(7):1952-7 DR EXPERIMENTAL; SP|Q58085
Genome PropertyGenProp0112: riboflavin, FAD and FMN from GTP and ribulose-5-P (HMM)