HMM Summary Page: TIGR01507

Functionsqualene-hopene cyclase
Gene Symbolshc
Trusted Cutoff431.10
Domain Trusted Cutoff431.10
Noise Cutoff386.85
Domain Noise Cutoff386.85
Isology Typeequivalog
EC Number5.4.99.17
HMM Length640
Mainrole CategoryFatty acid and phospholipid metabolism
Subrole CategoryOther
Gene Ontology TermGO:0019746: hopanoid biosynthetic process biological_process
GO:0051007: squalene-hopene cyclase activity molecular_function
AuthorBrinkac L
Entry DateMay 15 2002 3:01PM
Last ModifiedFeb 14 2011 3:27PM
CommentSHC is an essential prokaryotic gene in hopanoid (triterpenoid) biosynthesis. Squalene hopene cyclase, an integral membrane protein, directly cyclizes squalene into hopanoid products [1,2].
ReferencesRN [1] RM 97442532 RT Structure and function of a squalene cyclase RA Wendt KU, Lenhart A, Schulz GE. RL Science 277:1811-1815(1997) RN [2] RM PMID: 12120044 RT Squalene-hopene cyclase: catalytic mechanism and substrate recognition. RA Hoshino, T. and Sato, T. RL Chem. Commun. (2002) 291-301. DR PFAM; PF00432; Prenyltransferase/squalene oxidase repeat DR PROSITE; PS01074; Terpene Synthases DR EXPERIMENTAL; GP|3164082; Methylococcus capsulatus; heterologous expression in E.coli with in vitro activity of the recombinant cyclase demonstrated using crude cell-free lysate or solubilized membrane preparation DR EXPERIMENTAL; GP|2970047; Alicyclobacillus acidocaldarius; heterologous expression in E.coli with site-directed mutagenesis experimentation determining active site residues. DR HOMOLOGY; SP|P73914; Synechocystis sp.; homology based methodology and phylogenetic relationship. conservation of active site residues and structural motifs. DR OUTGROUP; GP|1098635; Rattus norvegicus; Oxidosqualene Cyclase
Genome PropertyGenProp0761: hopanoid lipid biosynthesis (HMM)