| Accession | TIGR01505 |
| Name | tartro_sem_red |
| Function | 2-hydroxy-3-oxopropionate reductase |
| Trusted Cutoff | 340.75 |
| Domain Trusted Cutoff | 340.75 |
| Noise Cutoff | 301.35 |
| Domain Noise Cutoff | 301.35 |
| Isology Type | equivalog |
| EC Number | 1.1.1.60 |
| HMM Length | 291 |
| Gene Ontology Term | GO:0008679: 2-hydroxy-3-oxopropionate reductase activity molecular_function |
| | GO:0046393: D-galactarate metabolic process biological_process |
| Author | Haft DH |
| Entry Date | May 13 2002 1:54PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents 2-hydroxy-3-oxopropionate reductase (EC 1.1.1.60), also called tartronate semialdehyde reductase. It follows glyoxylate carboligase and precedes glycerate kinase in D-glycerate pathway of glyoxylate degradation. The eventual product, 3-phosphoglycerate, is an intermediate of glycolysis and is readily metabolized. Tartronic semialdehyde, the substrate of this enzyme, may also come from other pathways, such as D-glucarate catabolism. |
| References | DR EXPERIMENTAL; SP|P77161|GLXR_ECOLI; E. coli; allantoin degradation
DR EXPERIMENTAL; SP|P23523|GARR_ECOLI; E. coli; glucaterate/galacterate degradation
RN [1]
RM 10762278
RT A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli.
RA Monterrubio R, Baldoma L, Obradors N, Aguilar J, Badia J.
RL J Bacteriol 2000 May;182(9):2672-4
RN [2]
RM 10601204
RT Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli.
RA Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J.
RL J Bacteriol 1999 Dec;181(24):7479-84 |
| Genome Property | GenProp0689: glyoxalate conversion to phosphoglycerate (HMM) |
| | GenProp0714: galactarate utilization via tartronate semi-aldehyde (HMM) |
| | GenProp0716: glucarate utilization via tartronate semi-aldehyde (HMM) |
