HMM Summary Page: TIGR01505

Function2-hydroxy-3-oxopropionate reductase
Trusted Cutoff340.75
Domain Trusted Cutoff340.75
Noise Cutoff301.35
Domain Noise Cutoff301.35
Isology Typeequivalog
EC Number1.1.1.60
HMM Length291
Gene Ontology TermGO:0008679: 2-hydroxy-3-oxopropionate reductase activity molecular_function
GO:0046393: D-galactarate metabolic process biological_process
AuthorHaft DH
Entry DateMay 13 2002 1:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents 2-hydroxy-3-oxopropionate reductase (EC, also called tartronate semialdehyde reductase. It follows glyoxylate carboligase and precedes glycerate kinase in D-glycerate pathway of glyoxylate degradation. The eventual product, 3-phosphoglycerate, is an intermediate of glycolysis and is readily metabolized. Tartronic semialdehyde, the substrate of this enzyme, may also come from other pathways, such as D-glucarate catabolism.
ReferencesDR EXPERIMENTAL; SP|P77161|GLXR_ECOLI; E. coli; allantoin degradation DR EXPERIMENTAL; SP|P23523|GARR_ECOLI; E. coli; glucaterate/galacterate degradation RN [1] RM 10762278 RT A common regulator for the operons encoding the enzymes involved in D-galactarate, D-glucarate, and D-glycerate utilization in Escherichia coli. RA Monterrubio R, Baldoma L, Obradors N, Aguilar J, Badia J. RL J Bacteriol 2000 May;182(9):2672-4 RN [2] RM 10601204 RT Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli. RA Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J. RL J Bacteriol 1999 Dec;181(24):7479-84
Genome PropertyGenProp0689: glyoxalate conversion to phosphoglycerate (HMM)
GenProp0714: galactarate utilization via tartronate semi-aldehyde (HMM)
GenProp0716: glucarate utilization via tartronate semi-aldehyde (HMM)