HMM Summary Page: TIGR01500

Functionsepiapterin reductase
Trusted Cutoff206.55
Domain Trusted Cutoff206.55
Noise Cutoff116.60
Domain Noise Cutoff116.60
Isology Typeequivalog
EC Number1.1.1.153
HMM Length255
AuthorHaft DH
Entry DateMay 8 2002 5:17PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes sepiapterin reductase, a member of the short chain dehydrogenase/reductase family. The enzyme catalyzes the last step in the biosynthesis of tetrahydrobiopterin. A similar enzyme in Bacillus cereus was isolated for its ability to convert benzil to (S)-benzoin, a property sepiapterin reductase also shares. Cutoff scores for this model are set such that benzil reductase scores between trusted and noise cutoffs.
ReferencesRM 11796169 RT The enzymes with benzil reductase activity conserved from bacteria to mammals. RA Maruyama R, Nishizawa M, Itoi Y, Ito S, Inoue M. RL J Biotechnol 2002 Mar 28;94(2):157-69