HMM Summary Page: TIGR01500
| Accession | TIGR01500 |
| Name | sepiapter_red |
| Function | sepiapterin reductase |
| Trusted Cutoff | 206.55 |
| Domain Trusted Cutoff | 206.55 |
| Noise Cutoff | 116.60 |
| Domain Noise Cutoff | 116.60 |
| Isology Type | equivalog |
| EC Number | 1.1.1.153 |
| HMM Length | 255 |
| Author | Haft DH |
| Entry Date | May 8 2002 5:17PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM describes sepiapterin reductase, a member of the short chain dehydrogenase/reductase family. The enzyme catalyzes the last step in the biosynthesis of tetrahydrobiopterin. A similar enzyme in Bacillus cereus was isolated for its ability to convert benzil to (S)-benzoin, a property sepiapterin reductase also shares. Cutoff scores for this model are set such that benzil reductase scores between trusted and noise cutoffs. |
| References | RM 11796169 RT The enzymes with benzil reductase activity conserved from bacteria to mammals. RA Maruyama R, Nishizawa M, Itoi Y, Ito S, Inoue M. RL J Biotechnol 2002 Mar 28;94(2):157-69 |