| Accession | TIGR01499 |
| Name | folC |
| Function | bifunctional protein FolC |
| Gene Symbol | folC |
| Trusted Cutoff | 162.65 |
| Domain Trusted Cutoff | 162.65 |
| Noise Cutoff | 125.05 |
| Domain Noise Cutoff | 125.05 |
| Isology Type | subfamily |
| EC Number | 6.3.2.- |
| HMM Length | 400 |
| Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
| Subrole Category | Folic acid |
| Gene Ontology Term | GO:0004326: tetrahydrofolylpolyglutamate synthase activity molecular_function |
| | GO:0005737: cytoplasm cellular_component |
| | GO:0006760: folic acid-containing compound metabolic process biological_process |
| | GO:0008841: dihydrofolate synthase activity molecular_function |
| | GO:0046654: tetrahydrofolate biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | May 7 2002 1:42PM |
| Last Modified | Feb 20 2011 4:43PM |
| Comment | This HMM represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC 6.3.2.17) and dihydrofolate synthetase (EC 6.3.2.12). The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1).
A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog. |
| References | RM 1989505
DR EXPERIMENTAL; bifunctional; Pseudomonas aeruginosa
DR EXPERIMENTAL; bifunctional; Escherichia coli
RT Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli.
RA Kimlova LJ, Pyne C, Keshavjee K, Huy J, Beebakhee G, Bognar AL.
RL Arch Biochem Biophys 1991 Jan;284(1):9-16 |
| Genome Property | GenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM) |
