HMM Summary Page: TIGR01499

Functionbifunctional protein FolC
Gene SymbolfolC
Trusted Cutoff162.65
Domain Trusted Cutoff162.65
Noise Cutoff125.05
Domain Noise Cutoff125.05
Isology Typesubfamily
EC Number6.3.2.-
HMM Length400
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0004326: tetrahydrofolylpolyglutamate synthase activity molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006760: folic acid-containing compound metabolic process biological_process
GO:0008841: dihydrofolate synthase activity molecular_function
GO:0046654: tetrahydrofolate biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 7 2002 1:42PM
Last ModifiedFeb 20 2011 4:43PM
CommentThis HMM represents the FolC family of folate pathway proteins. Most examples are bifunctional, active as both folylpolyglutamate synthetase (EC and dihydrofolate synthetase (EC The two activities are similar - ATP + glutamate + dihydropteroate or tetrahydrofolyl-[Glu](n) = ADP + orthophosphate + dihydrofolate or tetrahydrofolyl-[Glu](n+1). A mutation study of the FolC gene of E. coli suggests that both activities belong to the same active site. Because some examples are monofunctional (and these cannot be separated phylogenetically), the model is treated as subfamily, not equivalog.
ReferencesRM 1989505 DR EXPERIMENTAL; bifunctional; Pseudomonas aeruginosa DR EXPERIMENTAL; bifunctional; Escherichia coli RT Mutagenesis of the folC gene encoding folylpolyglutamate synthetase-dihydrofolate synthetase in Escherichia coli. RA Kimlova LJ, Pyne C, Keshavjee K, Huy J, Beebakhee G, Bognar AL. RL Arch Biochem Biophys 1991 Jan;284(1):9-16
Genome PropertyGenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM)