HMM Summary Page: TIGR01498

Function2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
Gene SymbolfolK
Trusted Cutoff54.10
Domain Trusted Cutoff54.10
Noise Cutoff32.60
Domain Noise Cutoff32.60
Isology Typeequivalog
EC Number2.7.6.3
HMM Length128
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryFolic acid
Gene Ontology TermGO:0003848: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity molecular_function
GO:0009396: folic acid-containing compound biosynthetic process biological_process
AuthorHaft DH
Entry DateMay 6 2002 5:12PM
Last ModifiedAug 12 2011 9:01AM
CommentThis HMM describes the folate biosynthesis enzyme 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. Alternate names include 6-hydroxymethyl-7,8-dihydropterin diphosphokinase and 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase (HPPK). The extreme C-terminal region, of typically eight to thirty residues, is not included in the model. This enzyme may be found as a fusion protein with other enzymes of folate biosynthesis.
ReferencesDR PFAM; PF01288 DR INTERPRO; IPR000550
Genome PropertyGenProp0038: tetrahydrofolate biosynthesis from GTP and PABA (HMM)