HMM Summary Page: TIGR01485

Functionsucrose phosphatase
Gene SymbolSPP
Trusted Cutoff183.65
Domain Trusted Cutoff183.65
Noise Cutoff100.05
Domain Noise Cutoff100.05
Isology Typeequivalog
EC Number3.1.3.24
HMM Length249
AuthorSelengut J
Entry DateApr 10 2002 10:20AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model describes the sucrose phosphate phosphohydrolase from plants and cyanobacteria (SPP). SPP is a member of the Class IIB subfamily (TIGR01484) of the Haloacid Dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases. SPP catalyzes the final step in the biosynthesis of sucrose, a critically important molecule for plants. Sucrose phosphate synthase (SPS), the prior step in the biosynthesis of sucrose, contains a domain which exhibits considerable similarity to SPP albeit without conservation of the catalytic residues. The catalytic machinery of the synthase resides in another domain. It seems likely that the phosphatase-like domain is involved in substrate binding, possibly binding both substrates in a "product-like" orientation prior to ligation by the synthase catalytic domain.
ReferencesRN [1] RM PMID: 11050182 RT Purification, molecular cloning, and sequence analysis of sucrose-6F-phosphate phosphohydrolase from plants. RA Lunn JE, Ashton AR, Hatch MD, Heldt HW. RL Proc Natl Acad Sci U S A 2000 Nov 7;97(23):12914-9