HMM Summary Page: TIGR01481

Functioncatabolite control protein A
Gene SymbolccpA
Trusted Cutoff442.35
Domain Trusted Cutoff442.35
Noise Cutoff328.65
Domain Noise Cutoff328.65
Isology Typeequivalog
HMM Length330
Mainrole CategoryRegulatory functions
Subrole CategoryDNA interactions
Gene Ontology TermGO:0003677: DNA binding molecular_function
GO:0005975: carbohydrate metabolic process biological_process
GO:0006355: regulation of transcription, DNA-dependent biological_process
GO:0016563: transcription activator activity molecular_function
GO:0016564: transcription repressor activity molecular_function
AuthorBeanan M
Entry DateApr 1 2002 11:21AM
Last ModifiedFeb 14 2011 3:27PM
CommentCatabolite control protein A is a LacI family global transcriptional regulator found in Gram-positive bacteria. CcpA is involved in repressing carbohydrate utilization genes [ex: alpha-amylase (amyE), acetyl-coenzyme A synthase (acsA)] and in activating genes involved in transporting excess carbon from the cell [ex: acetate kinase (ackA), alpha-acetolactate synthase (alsS)]. Additionally, disruption of CcpA in Bacillus megaterium, Staphylococcus xylosus, Lactobacillus casei and Lactocacillus pentosus also decreases growth rate, which suggests CcpA is involved in the regulation of other metabolic pathways.
ReferencesRN [1] RM PMID:10094627 RT Transcriptional activation of the glycolytic las operon and catabolite repression of the gal operon in Lactococcus lactis are mediated by the catabolite control protein CcpA. RA Luesink EJ, van Herpen RE, Grossiord BP, Kuipers OP, de Vos WM RL Mol Microbiol. 1998 Nov;30(4):789-98.