HMM Summary Page: TIGR01480

Functioncopper-resistance protein, CopA family
Trusted Cutoff478.95
Domain Trusted Cutoff478.95
Noise Cutoff291.40
Domain Noise Cutoff291.40
Isology Typesubfamily
HMM Length593
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0005375: copper ion transmembrane transporter activity molecular_function
GO:0005507: copper ion binding molecular_function
GO:0006825: copper ion transport biological_process
AuthorHaft DH
Entry DateMar 25 2002 3:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export.
Genome PropertyGenProp0890: copper homeostasis system CopRS/CopABCD (HMM)