| Accession | TIGR01480 |
| Name | copper_res_A |
| Function | copper-resistance protein, CopA family |
| Trusted Cutoff | 478.95 |
| Domain Trusted Cutoff | 478.95 |
| Noise Cutoff | 291.40 |
| Domain Noise Cutoff | 291.40 |
| Isology Type | subfamily |
| HMM Length | 593 |
| Mainrole Category | Cellular processes |
| Subrole Category | Detoxification |
| Gene Ontology Term | GO:0005375: copper ion transmembrane transporter activity molecular_function |
| | GO:0005507: copper ion binding molecular_function |
| | GO:0006825: copper ion transport biological_process |
| Author | Haft DH |
| Entry Date | Mar 25 2002 3:06PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This HMM represents the CopA copper resistance protein family. CopA is related to laccase (benzenediol:oxygen oxidoreductase) and L-ascorbate oxidase, both copper-containing enzymes. Most members have a typical TAT (twin-arginine translocation) signal sequence with an Arg-Arg pair. Twin-arginine translocation is observed for a large number of periplasmic proteins that cross the inner membrane with metal-containing cofactors already bound. The combination of copper-binding sites and TAT translocation motif suggests a mechansism of resistance by packaging and export. |
| Genome Property | GenProp0890: copper homeostasis system CopRS/CopABCD (HMM) |
