HMM Summary Page: TIGR01475

Functionputative 4-hydroxybenzoate polyprenyltransferase
Trusted Cutoff180.80
Domain Trusted Cutoff180.80
Noise Cutoff148.10
Domain Noise Cutoff148.10
Isology Typehypoth_equivalog
EC Number2.5.1.-
HMM Length282
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0006744: ubiquinone biosynthetic process biological_process
GO:0008412: 4-hydroxybenzoate octaprenyltransferase activity molecular_function
AuthorHaft DH
Entry DateMar 20 2002 2:40PM
Last ModifiedFeb 14 2011 3:27PM
CommentA fairly deep split separates this polyprenyltransferase subfamily from the set of mitochondrial and proteobacterial 4-hydroxybenzoate polyprenyltransferases, described in TIGR01474. Protoheme IX farnesyltransferase (heme O synthase) (TIGR01473) is more distantly related. Because no species appears to have both this protein and a member of TIGR01474, it is likely that this HMM represents 4-hydroxybenzoate polyprenyltransferase, a critical enzyme of ubiquinone biosynthesis, in the Archaea, Gram-positive bacteria, Aquifex aeolicus, the Chlamydias, etc.
Genome PropertyGenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)
GenProp0829: menaquinone biosynthesis via futalosine (HMM)