HMM Summary Page: TIGR01474

Function4-hydroxybenzoate polyprenyl transferase
Gene SymbolubiA
Trusted Cutoff275.45
Domain Trusted Cutoff275.45
Noise Cutoff160.95
Domain Noise Cutoff160.95
Isology Typeequivalog
EC Number2.5.1.-
HMM Length282
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryMenaquinone and ubiquinone
Gene Ontology TermGO:0006744: ubiquinone biosynthetic process biological_process
GO:0008412: 4-hydroxybenzoate octaprenyltransferase activity molecular_function
AuthorHaft DH
Entry DateMar 20 2002 2:21PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a family of integral membrane proteins that condenses para-hydroxybenzoate with any of several polyprenyldiphosphates. Heterologous expression studies suggest that for, many but not all members, the activity seen (e.g. octaprenyltransferase in E. coli) reflects available host isoprenyl pools rather than enzyme specificity. A fairly deep split by both clustering (UPGMA) and phylogenetics (NJ tree) separates this group (mostly Proteobacterial and mitochondrial), with several characterized members, from another group (mostly archaeal and Gram-positive bacterial) lacking characterized members.
ReferencesDR EXPERIMENTAL; SP:P32378; p-hydroxybenzoate:polyprenyl transferase; Saccharomyces cerevisiae DR EXPERIMENTAL; SP:P26601; 4-hydroxybenzoate octaprenyltransferase; Escherichia coli; ubiA DR EXPERIMENTAL; SP|O52366; 4-hydroxybenzoate octaprenyltransferase; Providencia stuartii; aarE RN [1] RM 11092853 RT Phenotypes of fission yeast defective in ubiquinone production due to disruption of the gene for p-hydroxybenzoate polyprenyl diphosphate transferase. RA Uchida N, Suzuki K, Saiki R, Kainou T, Tanaka K, Matsuda H, Kawamukai M. RL J Bacteriol 2000 Dec;182(24):6933-9 DR HAMAP; MF_01635; 160 of 167
Genome PropertyGenProp0136: ubiquinone biosynthesis from chorismate, aerobic (HMM)