HMM Summary Page: TIGR01472

FunctionGDP-mannose 4,6-dehydratase
Gene Symbolgmd
Trusted Cutoff415.00
Domain Trusted Cutoff415.00
Noise Cutoff103.25
Domain Noise Cutoff103.25
Isology Typeequivalog
EC Number4.2.1.47
HMM Length342
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of surface polysaccharides and lipopolysaccharides
Gene Ontology TermGO:0000271: polysaccharide biosynthetic process biological_process
GO:0008446: GDP-mannose 4,6-dehydratase activity molecular_function
AuthorHaft DH
Entry DateMar 18 2002 5:50PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: GDP-D-mannose dehydratase. This enzyme converts GDP-mannose to GDP-4-dehydro-6-deoxy-D-mannose, the first of three steps for the conversion of GDP-mannose to GDP-fucose in animals, plants, and bacteria. In bacteria, GDP-L-fucose acts as a precursor of surface antigens such as the extracellular polysaccharide colanic acid of E. coli. Excluded from this model are members of the clade that score poorly because of highly dervied (phylogenetically long-branch) sequences, e.g. Aneurinibacillus thermoaerophilus Gmd, described as a bifunctional GDP-mannose 4,6-dehydratase/GDP-6-deoxy-D-lyxo-4-hexulose reductase (PUBMED:11096116).
ReferencesDR EXPERIMENTAL; SP|O60547; Homo sapiens DR EXPERIMENTAL; OMNI|HP0044; Helicobacter pylori DR EXPERIMENTAL; SP|P32054; Escherichia coli DR EXPERIMENTAL; SP|Q9SNY3; Arabidopsis thaliana RN [1] RM 9525924 RT Molecular cloning of human GDP-mannose 4,6-dehydratase and reconstitution of GDP-fucose biosynthesis in vitro. RA Sullivan FX, Kumar R, Kriz R, Stahl M, Xu GY, Rouse J, Chang XJ, Boodhoo A, Potvin B, Cumming DA. RL J Biol Chem 1998 Apr 3;273(14):8193-202
Genome PropertyGenProp0930: GDP-4-keto-6-deoxymannose biosynthesis from b-D-fructose-6-phosphate (HMM)