Accession | TIGR01470 |
Name | cysG_Nterm |
Function | siroheme synthase, N-terminal domain |
Trusted Cutoff | 62.30 |
Domain Trusted Cutoff | 62.30 |
Noise Cutoff | 43.40 |
Domain Noise Cutoff | 43.40 |
Isology Type | subfamily_domain |
HMM Length | 205 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Heme, porphyrin, and cobalamin |
Gene Ontology Term | GO:0019354: siroheme biosynthetic process biological_process |
| GO:0043115: precorrin-2 dehydrogenase activity molecular_function |
| GO:0051266: sirohydrochlorin ferrochelatase activity molecular_function |
Author | Haft DH |
Entry Date | Mar 14 2002 1:59PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents a subfamily of CysG N-terminal region-related sequences. All sequences in the seed alignment for this model are N-terminal regions of known or predicted siroheme synthases. The C-terminal region of each is uroporphyrin-III C-methyltransferase (EC 2.1.1.107), which catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). The region represented by this model completes the process of oxidation and iron insertion to yield siroheme. Siroheme is a cofactor for nitrite and sulfite reductases, so siroheme synthase is CysG of cysteine biosynthesis in some organisms. |
References | RM 11114933
RT Alternative pathways for siroheme synthesis in Klebsiella aerogenes.
RA Kolko MM, Kapetanovich LA, Lawrence JG.
RL J Bacteriol 2001 Jan;183(1):328-35
DR HAMAP; MF_01646; 105 of 106 |
Genome Property | GenProp0194: siroheme biosynthesis from uroporphrinogen-III (HMM) |
| GenProp0194: siroheme biosynthesis from uroporphrinogen-III (HMM) |