Accession | TIGR01469 |
Name | cobA_cysG_Cterm |
Function | uroporphyrinogen-III C-methyltransferase |
Gene Symbol | cobA |
Trusted Cutoff | 185.00 |
Domain Trusted Cutoff | 185.00 |
Noise Cutoff | 184.25 |
Domain Noise Cutoff | 184.25 |
Isology Type | equivalog_domain |
EC Number | 2.1.1.107 |
HMM Length | 238 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Heme, porphyrin, and cobalamin |
Gene Ontology Term | GO:0004851: uroporphyrin-III C-methyltransferase activity molecular_function |
| GO:0019354: siroheme biosynthetic process biological_process |
Author | Haft DH |
Entry Date | Mar 13 2002 6:00PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | This HMM represents enzymes, or enzyme domains, with uroporphyrin-III C-methyltransferase activity. This enzyme catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). Cobalamin contains cobalt while siroheme contains iron. Siroheme is a cofactor for nitrite and sulfite reductases and therefore plays a role in cysteine biosynthesis; many members of this family are CysG, siroheme synthase, with an additional N-terminal domain and with additional oxidation and iron insertion activities. |
References | DR HAMAP; MF_01646; 105 of 106 |
Genome Property | GenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM) |
| GenProp0194: siroheme biosynthesis from uroporphrinogen-III (HMM) |
| GenProp0275: cobyrinic acid diamide biosynthesis, anaerobic pathway (HMM) |