HMM Summary Page: TIGR01469

Functionuroporphyrinogen-III C-methyltransferase
Gene SymbolcobA
Trusted Cutoff185.00
Domain Trusted Cutoff185.00
Noise Cutoff184.25
Domain Noise Cutoff184.25
Isology Typeequivalog_domain
EC Number2.1.1.107
HMM Length238
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0004851: uroporphyrin-III C-methyltransferase activity molecular_function
GO:0019354: siroheme biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 13 2002 6:00PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents enzymes, or enzyme domains, with uroporphyrin-III C-methyltransferase activity. This enzyme catalyzes the first step committed to the biosynthesis of either siroheme or cobalamin (vitamin B12) rather than protoheme (heme). Cobalamin contains cobalt while siroheme contains iron. Siroheme is a cofactor for nitrite and sulfite reductases and therefore plays a role in cysteine biosynthesis; many members of this family are CysG, siroheme synthase, with an additional N-terminal domain and with additional oxidation and iron insertion activities.
ReferencesDR HAMAP; MF_01646; 105 of 106
Genome PropertyGenProp0113: cobyrinic acid diamide biosynthesis, aerobic pathway (HMM)
GenProp0194: siroheme biosynthesis from uroporphrinogen-III (HMM)
GenProp0275: cobyrinic acid diamide biosynthesis, anaerobic pathway (HMM)