HMM Summary Page: TIGR01464

Functionuroporphyrinogen decarboxylase
Gene SymbolhemE
Trusted Cutoff302.95
Domain Trusted Cutoff302.95
Noise Cutoff140.60
Domain Noise Cutoff140.60
Isology Typeequivalog
EC Number4.1.1.37
HMM Length338
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0004853: uroporphyrinogen decarboxylase activity molecular_function
GO:0006779: porphyrin-containing compound biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 12 2002 8:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents uroporphyrinogen decarboxylase (HemE), which converts uroporphyrinogen III to coproporphyrinogen III. This step takes the pathway toward protoporphyrin IX, a common precursor of both heme and chlorophyll, rather than toward precorrin 2 and its products.
References DR HAMAP; MF_00218; 370 of 374
Genome PropertyGenProp0221: protoporphyrin IX biosynthesis from uroporphyrinogen III (HMM)