HMM Summary Page: TIGR01463

Functionmethyltransferase, MtaA/CmuA family
Trusted Cutoff235.40
Domain Trusted Cutoff235.40
Noise Cutoff103.65
Domain Noise Cutoff103.65
Isology Typesubfamily
EC Number2.1.1.-
HMM Length340
AuthorHaft DH
Entry DateMar 11 2002 5:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis subfamily is closely related to, yet is distinct from, uroporphyrinogen decarboxylase (EC It includes two isozymes from Methanosarcina barkeri of methylcobalamin--coenzyme M methyltransferase. It also includes a chloromethane utilization protein, CmuA, which transfers the methyl group of chloromethane to a corrinoid protein.
ReferencesRN [1] RM 11133460 RT Chloromethane utilization gene cluster from Hyphomicrobium chloromethanicum strain CM2(T) and development of functional gene probes to detect halomethane-degrading bacteria. RA McAnulla C, Woodall CA, McDonald IR, Studer A, Vuilleumier S, Leisinger T, Murrell JC. RL Appl Environ Microbiol 2001 Jan;67(1):307-16 RN [2] RM 8654414 RT Methylcobalamin: coenzyme M methyltransferase isoenzymes MtaA and MtbA from Methanosarcina barkeri. Cloning, sequencing and differential transcription of the encoding genes, and functional overexpression of the mtaA gene in Escherichia coli. RA Harms U, Thauer RK. RL Eur J Biochem 1996 Feb 1;235(3):653-9