HMM Summary Page: TIGR01458

FunctionHAD hydrolase, TIGR01458 family
Trusted Cutoff175.95
Domain Trusted Cutoff175.95
Noise Cutoff118.50
Domain Noise Cutoff118.50
Isology Typehypoth_equivalog
HMM Length257
Mainrole CategoryUnknown function
Subrole CategoryEnzymes of unknown specificity
Gene Ontology TermGO:0008152: metabolic process biological_process
GO:0016787: hydrolase activity molecular_function
AuthorSelengut J
Entry DateMar 6 2002 10:35AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis hypothetical equivalog is a member of the IIA subfamily (TIGR01460) of the haloacid dehalogenase superfamily of aspartate-nucleophile hydrolases. One sequence (GP|10716807) has been annotated as a "phospholysine phosphohistidine inorganic pyrophosphatase," probably in reference to studies on similarly described (but unsequenced) enzymes from bovine and rat tissues [1,2]. However, the supporting information for this annotation has never been published.
ReferencesRN [1] RM PMID: 9448729 RT 3-phosphohistidine and 6-phospholysine are substrates of a 56-kDa inorganic pyrophosphatase from bovine liver. RA Hiraishi H, Yokoi F, Kumon A. RL Arch Biochem Biophys 1998 Jan 15;349(2):381-7 RN [2] RM PMID: 7822258 RT 3-Phosphohistidine/6-phospholysine phosphatase from rat brain as acid phosphatase. RA Ohmori H, Kuba M, Kumon A. RL J Biochem (Tokyo) 1994 Aug;116(2):380-5