HMM Summary Page: TIGR01455

Functionphosphoglucosamine mutase
Gene SymbolglmM
Trusted Cutoff447.55
Domain Trusted Cutoff447.55
Noise Cutoff339.25
Domain Noise Cutoff339.25
Isology Typeequivalog
EC Number5.4.2.10
HMM Length442
Mainrole CategoryCell envelope
Subrole CategoryBiosynthesis and degradation of murein sacculus and peptidoglycan
Gene Ontology TermGO:0008966: phosphoglucosamine mutase activity molecular_function
GO:0009103: lipopolysaccharide biosynthetic process biological_process
GO:0009252: peptidoglycan biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 1 2002 10:31AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM describes GlmM, phosphoglucosamine mutase, also designated in MrsA and YhbF E. coli, UreC in Helicobacter pylori, and femR315 or FemD in Staphlococcus aureus. It converts glucosamine-6-phosphate to glucosamine-1-phosphate as part of the pathway toward UDP-N-acetylglucosamine for peptidoglycan and lipopolysaccharides.
ReferencesDR EXPERIMENTAL; OMNI|SA2151; Staphylococcus aureus DR EXPERIMENTAL; SP:P25177; Helicobacter pylori DR EXPERIMENTAL; PIR:I41215; Escherichia coli RN [1] RM 8550580 RT Characterization of the essential gene glmM encoding phosphoglucosamine mutase in Escherichia coli. RA Mengin-Lecreulx D, van Heijenoort J. RL J Biol Chem 1996 Jan 5;271(1):32-9 RN [2] RM 9171391 RT The Helicobacter pylori ureC gene codes for a phosphoglucosamine mutase. RA De Reuse H, Labigne A, Mengin-Lecreulx D. RL J Bacteriol 1997 Jun;179(11):3488-93 RN [3] RM 9286983 RT The femR315 gene from Staphylococcus aureus, the interruption of which results in reduced methicillin resistance, encodes a phosphoglucosamine mutase. RA Jolly L, Wu S, van Heijenoort J, de Lencastre H, Mengin-Lecreulx D, Tomasz A. RL J Bacteriol 1997 Sep;179(17):5321-5 DR HAMAP; MF_01554; 469 of 502
Genome PropertyGenProp0750: UDP-N-acetylglucosamine biosynthesis from fructose-6-phosphate (HMM)