HMM Summary Page: TIGR01443

Functionintein C-terminal splicing region
Trusted Cutoff15.60
Domain Trusted Cutoff14.80
Noise Cutoff14.00
Domain Noise Cutoff12.00
Isology Typedomain
HMM Length24
AuthorHaft DH
Entry DateFeb 13 2002 1:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents the well-conserved C-terminal region of a large number of inteins. It is based on interated search results, starting with a curated collection of intein N-terminal splicing regions from InBase, the New England Biolabs Intein Database, as presented on its web site. Inteins are regions encoded within proteins from which they remove themselves after translation in a self-splicing reaction, leaving the remainder of the coding region to form a complete, functional protein as if the intein were never there. Proteins with inteins include RecA, GyrA, ribonucleotide reductase, and others. Most inteins have a central region with putative endonuclease activity.
ReferencesDR URL;; InBase, The New England Biolabs Intein Database DR HAMAP; MF_01509; 2 of 38
Genome PropertyGenProp0010: inteins (HMM)