HMM Summary Page: TIGR01436

Functionglutamate--cysteine ligase
Trusted Cutoff463.15
Domain Trusted Cutoff463.15
Noise Cutoff90.55
Domain Noise Cutoff90.55
Isology Typeequivalog
EC Number6.3.2.2
HMM Length446
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0004357: glutamate-cysteine ligase activity molecular_function
GO:0006750: glutathione biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 5 2002 3:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis HMM represents one of two highly dissimilar forms of glutamate--cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme of glutathione biosynthesis. The other type is modeled by TIGR01434. This type is found in plants (with a probable transit peptide), root nodule and other bacteria, but not E. coli and closely related species.
Genome PropertyGenProp0030: glutathione biosynthesis (HMM)