HMM Summary Page: TIGR01435

Functionglutamate--cysteine ligase/glutathione synthase
Gene SymbolgshAB
Trusted Cutoff656.00
Domain Trusted Cutoff656.00
Noise Cutoff338.35
Domain Noise Cutoff338.35
Isology Typeequivalog
EC Number6.3.2.2
HMM Length719
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0004357: glutamate-cysteine ligase activity molecular_function
GO:0004363: glutathione synthase activity molecular_function
GO:0006750: glutathione biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 5 2002 12:12PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis model represents a bifunctional protein family for the biosynthesis of glutathione, and perhaps a range of related gamma-glutamyltripeptides of the form gamma-Glu-Cys-X(aa). The N-terminal region is similar to proteobacterial glutamate-cysteine ligase. The C-terminal region is homologous to cyanophycin synthetase of cyanobacteria and, more distantly, to D-alanine-D-alanine ligases. Members of this HMM family are found in Listeria and Enterococcus, Gram-positive lineages in which glutathione is produced (see PUBMED:8606174), and in Pasteurella multocida, a Proteobacterium. In Clostridium acetobutylicum, adjacent genes include separate proteins rather than a fusion protein.
ReferencesRN [1] RM 17123467 RT Novel substrate specificity of glutathione synthesis enzymes from Streptococcus agalactiae and Clostridium acetobutylicum. RA Kino K, Kuratsu S, Noguchi A, Kokubo M, Nakazawa Y, Arai T, Yagasaki M, Kirimura K. RL Biochem Biophys Res Commun. 2007 Jan 12;352(2):351-9. DR HAMAP; MF_00782; 13 of 13
Genome PropertyGenProp0030: glutathione biosynthesis (HMM)
GenProp0030: glutathione biosynthesis (HMM)