HMM Summary Page: TIGR01434

Functionglutamate--cysteine ligase
Gene SymbolgshA
Trusted Cutoff393.30
Domain Trusted Cutoff393.30
Noise Cutoff223.85
Domain Noise Cutoff223.85
Isology Typeequivalog
EC Number6.3.2.2
HMM Length512
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryGlutathione and analogs
Gene Ontology TermGO:0004357: glutamate-cysteine ligase activity molecular_function
GO:0006750: glutathione biosynthetic process biological_process
AuthorHaft DH
Entry DateFeb 4 2002 5:53PM
Last ModifiedFeb 14 2011 3:27PM
CommentAlternate name: gamma-glutamylcysteine synthetase. This HMM represents glutamate--cysteine ligase, and enzyme in the biosynthesis of glutathione (GSH). GSH is one of several low molecular weight cysteine derivatives that can serve to protect against oxidative damage and participate in a biosynthetic or detoxification reactions.
ReferencesClostridium acetobutylicum candidate is short, is from an actinomycete (mycothione expected instead), and scores between trusted and noise. DR HAMAP; MF_00578; 64 of 66
Genome PropertyGenProp0030: glutathione biosynthesis (HMM)