HMM Summary Page: TIGR01433

Functionubiquinol oxidase, subunit II
Gene SymbolcyoA
Trusted Cutoff266.20
Domain Trusted Cutoff266.20
Noise Cutoff218.75
Domain Noise Cutoff218.75
Isology Typeequivalog
EC Number1.10.3.-
HMM Length226
Mainrole CategoryEnergy metabolism
Subrole CategoryElectron transport
Gene Ontology TermGO:0008827: cytochrome o ubiquinol oxidase activity molecular_function
GO:0015990: electron transport coupled proton transport biological_process
GO:0016021: integral to membrane cellular_component
AuthorSelengut J
Entry DateFeb 4 2002 11:54AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the oxidation of ubiquinol with the concomitant reduction of molecular oxygen to water. This acts as the terminal electron acceptor in the respiratory chain. Subunit II is responsible for binding and oxidation of the ubiquinone substrate. This sequence is closely related to QoxA, which oxidizes quinol in gram positive bacteria but which is in complex with subunits which utilize cytochromes a in the reduction of molecular oxygen. Slightly more distantly related is subunit II of cytochrome c oxidase which uses cyt. c as the oxidant.
ReferencesRN [1] RM 2162835 RT The sequence of the cyo operon indicates substantial structural similarities between the cytochrome o ubiquinol oxidase of Escherichia coli and the aa3-type family of cytochrome c oxidases RA Chepuri V, Lemieux L, Au DC, Gennis RB RL J Biol Chem 1990 Jul 5;265(19):11185-92 DR EXPERIMENTAL; EGAD|20044; Escherichia coli CyoA DR OUTGROUP; SP|P34957; Bacillus subtilis QoxA
Genome PropertyGenProp0618: cytochrome (quinone) oxidase, bo type (HMM)